日本小児肝臓研究所概要

NPO法人 日本小児肝臓研究所
理事長　藤澤知雄（ふじさわ ともお、Fujisawa Tomoo）

現職
済生会横浜市東部病院小児肝臓消化器科　顧問
東邦大学医学部客員教授
NPO法人 日本小児肝臓研究所　理事長

略歴
1969 早稲田大学教育学部生物学科中退
1975 日本大学医学部卒業
同年～1979 関東逓信病院(現NTT東日本関東病院)小児科研修医・専修医
この間に神奈川県立こども医療ｾﾝﾀｰ麻酔科、東京女子医大心研小児科に在籍
2000 防衛医科大学校　助教授
2003 国際医療福祉大学小児科教授
2007 済生会横浜市東部病院こどもｾﾝﾀｰ部長
2013 済生会横浜市東部病院小児肝臓消化器科顧問

学位
昭和60年(1985年）3月
「B型肝炎ｳｲﾙｽ(HBV)の母子垂直感染と抗HBsﾋﾄ免疫ｸﾞﾛﾌﾞﾘﾝおよびHBﾜｸﾁﾝ併用によるその予防」（日本大学第3123号）

専門領域、社会的活動(資格)、業績
専門領域：肝臓学、感染症
社会的活動：日本肝臓学会評議員、日本肝臓学会専門医指導医、日本小児肝臓研究会運営委員長、日本小児栄養消化器肝臓学会学術委員長、武蔵野小児肝臓病懇話会代表世話人、第27回日本小児栄養消化器病学会会長(2000)、第21回日本小児肝臓研究会会長(2004)、厚生労働省研究班「ｳｲﾙｽ母子感染防止に関する研究」、「難治性の肝疾患に関する調査研究」、「特殊免疫ｸﾞﾛﾌﾞﾘﾝの国内製造に係わる基礎整備に関する研究」の分担研究者
業績：Hepatology, J Hepatology, J Pediatrics, Blood, Lancetなど小児の感染症・肝疾患・代謝疾患に関する論文
主な肝臓関係の論文（英文論文のみ） Fujisawa T, Inui A, Ohkawa T, et al. Response to IFN therapy in children with chronic hepatitis C. J Pediatr, 127, 660-2, 1995Inui A, Fujisawa T, Miyagawa Y, et al. Histology activity of the liver in children with transfusion-associated chronic hepatitis C. J Hepatology, 21, 748-53, 1994Inui A, Fujisawa T, Komatsu H, et al. Histological improvement in native liver after auxiliary partial liver transplantation for ornithine transcarbamylase deficiency Lancet, 348, 751-2, 1996Komatsu H, Fujisawa T, Inui A, et al. Efficacy of IFN in treating chronic hepatitis C in children with a history of acute leukemia. BLOOD, 87, 4072-5, 1996Fujisawa T, Onoue M, Inui A, Kosugi T. Serial changes in titers of antibody to hepatitis B surface antigen after immunization of infants born to mothers with hepatitis B e antigen. J Pefiatr Gastroenterol Nutr. 23, 270-273, 1996Fujisawa T, Komatsu H, Inui A. et al. Spontaneous remission of chronic hepatitis in children. Eur J Pediatr, 156, 773-6, 1997Komatsu H, Fujisawa T, Inui A, et al. Mutations in the nonstructural protein 5A gene and response to IFN therapy in young patients with chronic hepatitis C virus 1b infection. J Med Virol, 53, 361-5, 1997Komatsu H, Fujisawa T, Inui A, et al. GBV-C/HGV infection in children with chronic hepatitis C. J Med Virol, 59, 154-9, 1999Kage M, Fujisawa T, Shiraki K, et al. Pathology of chronic hepatitis C in children. Hepatology, 26, 771-5, 1997Fujisawa T, Inui A, Komatsu H, Ohkawa T, Sogo T, Niyagawa Y. Hepatitis B precore mutation in children with chronic hepatitis B virus infection. Pediatr Int, 41, 603-608, 1999Fujisawa T, Komatsu H, Inui A, et al. Long-term outcome of chronic hepatitis B in adolescents and young adults in follow-up from childhood. J Pediatr Gastroenterol Nutr, 30. 201-6, 2000Fujisawa T, Inui A, Komatsu H, Sogo T, et al. A comparative study on pathologic features of chronic hepatitis C and B in pediatric patients. Pediatric Pathology and Molecular Medicine. 19: 469-480, 2000Komatsu H, Fujisawa T, et al. Acute self-limiting hepatitis B after immunoprophylaxis　failure in an infant. J Med Virol. 66, 28-33, 2002Komatsu H, Inui A, Sogo T, Kuroda K, Tanaka T, Fujisawa T, et al. TTV infection in children born to mothers infected with TTV but not with HBV, HCV, or HIV. J Med Virol. 74:499-506, 2004Nagasaka H, Yorifuji T, Egawa H, Yanai H, Fujisawa T, Kosugiyama K, Matsui A, Hasegaea M, Okada T, Takayanagi M, Chiba H, Kobayashi K. Evaluation of risk for atherosclerosis in Alagille syndrome and progressive familial intrehepatic cholestasis: two congenital cholestatic disease with different lipoprotein metabolisms. J Pediatr. 146: 329-35, 2005Inui A, Fujisawa T, Kubo T, Sogo T, Komatsu H, Kagata Y. A case of neonatal hemochromatosis-like liver failure with spontaneous remission. JPGN. 40:374-377, 2005Inui A, Sogo T, Komatsu H, Miyakawa H, Fujisawa T. Antibodies against cytokeratin 8/18 in apatient with de novo autoimmune hepatitis after living-donor liver transplantation. Liver Transpl. 11: 504-7, 2005Komatsu　H, Inui A, Sogo T, Fujisawa T, Egawa H, Tanaka K. Severe hypogammaglobulinemia associated with hepatic vein stenosis causes cytomegalovirus infection after living-related transplantation. Transpl Infect Dis. 7: 41-44, 2005Nagasaka H, Inoue I, Inui　A, Komatsu H, Sogo T, Murayama K, Murakami T, Yorifuji T, Asayama K, Katayama S, Uemoto S, Kobayashi K, Takayanagi M, Fujisawa T, Tsukahara H. Relatiionship between oxidative stress and antioxidant systems in the liver of patients with Wilson disease: hepatic manifestation in Wilson disease as a consequence of augmented oxidative stress. Pediatr Res. 60 (4): 472-7, 2006;Inui A, Komatsu H, Sogo T, Nagai T, Abe Kenji, and Fujisawa T. Hepatitis B virus Genotypes in children and adolescents in Japan: Before and after after immunization for the prevention of mother to infant transmission of HBV. J Med Virol. 79:670-675, 2007Fujisawa T, Sogo T, Komatsu H, Inui A. Autoimmune hepatitis in childhood. Hepatol Res. 37:S496-500, 2007.Murray KF, Shah U, Mohan N, Heller S, Gonzalez-Peralta RP, Kelly D, Chang MH, Mieeli-Vergani G, Jara P, Fujisawa T. Chronic Hepatitis. J Pediatr Gastroentel Nutr. 47: 225-233, 2008Shah U, Kelly D, Chang MH, Fujisawa T, Heller S, Gonzalez-Peralta RP, Jara P, Mieli-Vergani G, Mohan N, Murray KF. Management of chronic hepatitis B in children. J Pediatr Gastroenterol Nutr. 2009, 48 (4): 399-404Mieli-Vergani G, Heller S, Jara P, Vergani D, Chang MH, Fujisawa T, Gonzalez-Peralta RP, Kelly D, Mohan N, Shah U, Murray KF. Autoimmue hepatitis. J Pediatr Gastroenterol Nutr. 2009; 49 (2): 158-64lKomatsu H, Inui A, Sogo T, Hiejima E, Kudo N, Fujisawa T. Source of transmission in children with chronic hepatitis B infection after the implementation of a strategy for prevention in those at high risk. Hepatol Res. 2009 39: 569-76 Epub 2009 Feb 24Sogo T, Nagasaka H, Komatsu H, Inui A, Miida T, Callea F, Francalani P, Hirano K, Kitamura H, Yorifuji T, Fujisawa T. Fibrinogen storage disease caused by Aguadilla mutation presenting with hypobeta-lipoproteinemia and considerable liver disease. J Pediatr Gastroenterol Nutr. 2009: 49:133-6Aomatsu T, Komatsu H, Yoden A, Hosomi A, Miyazaki H, Sogo T, Inui AS, Fujisawa T, Tamai H. Fulminant hepatitis B and acute hepatitis B due to inyrafamilial transmission of HBV after chemotherapy for non-Hodgkin’s lymphoma in an HBV carrier. Eur J Pediatr. 2009 24.Koamstu H, Nojiri H, Sogo T, Inui A, Sawa F, Fujisawa T. Sarcoiliitis infected with group A streptococcus in a child presenting with confusion and combativeness. J Infect Chemother. 2009. 15:328-30.Tajiri H, Inui A, Kiyohara Y, Suzuki M, Kagimoto S, Etani Y, Shimizu T, Fujisawa T. Peginterferon alpha-2b and ribavirin for the treatment of chronic hepatitis C in Japanese pediatric and young adult patients: a survey of the Japan Society of Pediatric Hepatology. Eur J Gastroenterl Hepatol 2009. 21: 1256-1260,2009Komatsu H, Sugawara H, Matsuoka M, Tsunoda T, Hirata G, Sogo T, Hanata M, inui A, Fujisawa T. Clinical features of children with pneumonia from awine-origine influenza A virus H1N1: A single center experience in Japan. Pediatric International. 53: 115-119, 2011Shimizu N, Fujiwara T, Ohnishi S, Sato M, Kodama H, Kohsaka T, Inui A, FujisawaT, TamaiH,IDA S, Itoh S,Ito M, Horiike N, Harada M, Yoshino M, Aoki T. Effects of long-termZinc reatment in Jaoanese patients with Wilson disease: efficacy, stability, and coppermetabolism. Translation Research 2010; 156: 350-357Tsunoda T, Inui A, Etani Y, Kiyohara Y, Sugiura T, Ito K, Miyazawa R, Nagata I, Ida SFujisawa T. Efficacy or pegylated interferon-Α2a monotherapy in Japanese children withchronic hepatitis C. Hepatology Reseach 2011;41:399-404Hiejima E, Komatsu H, Sogo T, Inui A, Fujisawa T. Utility of simplified criteria for diagnosisof autoimmue hepatitis in children. JPGN 2011;52:470-473Komatsu H, Inui A, Sogo T, Tateno A, Shimokawa R, Fujisawa T. Tears from children with chronichepatitis B virus (HBV)infection are infectious vehicles of HBV transmission by tears, using micewith chimeric human livers JID 2012:206: 478-485Tsunoda T, Inui A, Kawamoto A, Sogo, Koamatsu H, Fujisawa T. Effect of pegylated rferon-alfa-2amonotherapy on growth in Japanese children with chronic hepatitis C. Hepatology Res. 2013 March 27 [Epub ahead of print]komatsu H, Inui A, Tsunoda T, Sogo T, Fujisawa T. Association between an IL-28 polymorphism and the efficacy of the response-guided pegylated interferon therapy in children with chrionic hepatitis C infection. Hepatology Res. 2013 April 43:327-38